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The precise mechanisms by which topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown. however.preclinical studies have revealed four properties that may contribute to topiramate’s efficacy for epilepsy and migraine prophylaxis. Electrophysiological and biochemical evidence suggests that topiramate.at pharmacologically relevant concentrations.blocks voltage-dependent sodium channels.augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABA-A receptor.antagonizes the AMPA/kainate subtype of the glutamate receptor.and inhibits the carbonic anhydrase enzyme.particularly isozymes II and IV.

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Taking Topamaz during pregnancy can increase the risk that your baby will develop cleft lip or a cleft palate. However.if you order topamax without prescription using order topamax without prescription medication to prevent seizures and become pregnant.it’s important that you tell your doctor right away. You should not stop taking Topamax unless your physician advises you to do so.

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