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PROGRAF may increase hyperglycemia in pregnant women with diabetes (including gestational diabetes). Monitor maternal blood glucose levels regularly [see WARNINGS AND PRECAUTIONS ].

Do not take PROGRAF if you are allergic to tacrolimus or any of the ingredients in PROGRAF.

Post-transplant lymphoproliferative disorder (PTLD) has been reported in immunosuppressed organ transplant recipients. The majority of PTLD events appear related to Epstein Prograf costa rica Virus (EBV) infection. The risk of PTLD appears greatest in those individuals who are EBV seronegative.a population which includes many young children.

PROGRAF may cause a spectrum of neurotoxicities. The most severe neurotoxicities include posterior reversible encephalopathy syndrome (PRES).delirium.seizure and coma. others include tremors.paresthesias.headache.mental status changes.and changes in motor and sensory functions [see ADVERSE REACTIONS ]. As symptoms may be associated with tacrolimus whole blood trough concentrations at or above the recommended range.monitor for neurologic symptoms and consider dosage reduction or discontinuation of PROGRAF if neurotoxicity occurs.

While using may need frequent blood tests. Your blood pressure will need to be checked often.

Call your doctor right away if you have any signs of infection.such as fever.chills.body warmth or redness.or flu symptoms.

Prograf therapy requires careful monitoring by adequately qualified and equipped personnel. The medicinal product should only be prescribed.and changes in immunosuppressive therapy physicians experienced in prograf costa rica therapy and the management of transplant patients.

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